Temazolamide in breast cancer with brain metastasis

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By Caroline Helwick July 25, Advertisement. The N study randomized patients with a variety of solid tumors and 1 to 3 brain metastases to undergo stereotactic radiosurgery alone or with whole-brain radiation therapy. The primary endpoint was the effect on cognitive function with the addition of whole-brain radiation therapy to stereotactic radiosurgery. The use of stereotactic radiosurgery alone, compared with stereotactic radiosurgery plus whole-brain radiation therapy, resulted in less cognitive deterioration at 3 months and better quality of life, and there was no difference in overall survival. Cognitive deterioration after stereotactic radiosurgery alone was observed in 40 of 63 patients She and her colleagues at Duke University Medical Center evaluated patients who underwent brain biopsy after stereotactic radiosurgery.
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Discussing Brain Metastases in Breast Cancer

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Breast Cancer Topic: Temodar for brain mets

In some breast cancer patients, tumor cells in red spread to the brain. CCR researchers are investigating whether the drug temozolomide in combination with another drug can prevent these brain lesions. Credit: Brunilde Gril, Ph. If a woman is diagnosed with breast cancer in the early stages of the disease, her chances of survival are high.
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Breast Cancer and Brain Metastases: Whole-Brain Radiotherapy May Not Be the Answer

We performed a meta-analysis of randomized clinical trials to compare the efficacy of brain radiotherapy RT combined with temozolomide TMZ versus RT alone as first-line treatment for brain metastases BM. Two investigators reviewed the abstracts and independently rated the quality of trials and relevant data. The primary outcome was overall survival OS. Seven studies were selected from the literature search.
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It is an alkylating agent used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme. Temozolomide is contraindicated in patients with hypersensitivity to it or to the similar drug dacarbazine. The use of temozolomide is not recommended in patients with severe myelosuppression.
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